{"id":30,"date":"2020-04-29T23:53:00","date_gmt":"2020-04-29T23:53:00","guid":{"rendered":"https:\/\/avo6.com\/index.php\/2020\/04\/29\/tout-savoir-sur-le-virus-de-la-rage\/"},"modified":"2022-09-28T20:26:44","modified_gmt":"2022-09-28T20:26:44","slug":"tout-savoir-sur-le-virus-de-la-rage","status":"publish","type":"post","link":"https:\/\/avo6.com\/?p=30","title":{"rendered":"Tout Savoir Sur le Virus de la Rage"},"content":{"rendered":"
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C\u2019est un virus qui provoque une m\u00e9ningo-enc\u00e9phalite (inflammation des m\u00e9ninges et de tout l\u2019enc\u00e9phale) virale, animale, transmise accidentellement \u00e0 l\u2019homme.<\/span><\/div>\n
\u00a0\u00a0\u00a0\u00a0 <\/span>Toute rage humaine est mortelle \u00ab\u00a0le traitement est uniquement pr\u00e9ventif <\/ins> par la vaccination\u00a0\u00bb<\/span><\/div>\n

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I.\u00a0\u00a0 <\/span><\/span><\/span><\/b>Caract\u00e8res virologique\u00a0:<\/span><\/b><\/div>\n
1)<\/span><\/span><\/b>Morphologie\u00a0:<\/span><\/u><\/b><\/div>\n
b <\/span><\/span>Virus allong\u00e9 en forme d\u2019un obus<\/span><\/div>\n
b <\/span><\/span>Sym\u00e9trie h\u00e9lico\u00efdale <\/span><\/div>\n
b <\/span><\/span>Envelopp\u00e9, spicul\u00e9 \u00ab\u00a0support de l\u2019h\u00e9magglutinine\u00a0\u00bb <\/span><\/div>\n
b <\/span><\/span>Ac nucl\u00e9ique est de l\u2019ARN<\/span><\/div>\n
b <\/span><\/span>Appartient \u00e0 la famille des lyssavirus<\/span><\/div>\n
b <\/span><\/span>Extr\u00eamement fragile, sensible \u00e0 la chaleur, la lumi\u00e8re et tr\u00e8s facilement d\u00e9truit par les d\u00e9tergents (savon, \u00e9ther, alcool\u2026\u2026)<\/span><\/div>\n
2)<\/span><\/span><\/b>Caract\u00e8res antig\u00e9niques\u00a0:<\/span><\/u><\/b><\/div>\n
\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span>i.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><\/i>Antig\u00e8ne (Ag) soluble\u00a0:<\/span><\/i> support\u00e9 par la nucl\u00e9oprot\u00e9ine<\/i><\/span><\/div>\n
\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span>ii.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><\/i>Ag d\u2019enveloppe\u00a0:<\/span><\/i> support\u00e9 par l\u2019h\u00e9magglutinine<\/i><\/span><\/div>\n
\u00a0\u00a0\u00a0\u00a0 <\/span>Il n\u2019y a pas de variants (un seul virus)<\/u><\/span><\/div>\n
II.\u00a0\u00a0 <\/span><\/span><\/span><\/b>Epid\u00e9miologie\u00a0:<\/span><\/b><\/div>\n
\u00a0\u00a0\u00a0\u00a0 <\/span>C\u2019est une maladie essentiellement des mammif\u00e8res, on distingue\u00a0:<\/span><\/div>\n
v <\/span><\/span>Rage citadine\u00a0:<\/span><\/u>li\u00e9e \u00e0 l\u2019infection d\u2019un certain nombre d\u2019animaux domestiques<\/span><\/div>\n
v <\/span><\/span>Rage selvatique\u00a0:<\/span><\/u>li\u00e9e \u00e0 l\u2019infection d\u2019animaux sauvages<\/u><\/span><\/div>\n
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III.\u00a0\u00a0 <\/span><\/span><\/span><\/b>Pouvoir pathog\u00e8ne\u00a0:<\/span><\/b><\/div>\n
1)<\/span><\/span><\/b>Clinique\u00a0:<\/span><\/u><\/b><\/div>\n
\u00a0\u00a0\u00a0\u00a0 <\/span>La rage humaine est toujours cons\u00e9cutive apr\u00e8s une morsure ou un l\u00e9chage par un animal infect\u00e9.<\/span><\/div>\n
a)\u00a0 <\/span><\/span><\/span><\/i><\/b>Incubation\u00a0:<\/span><\/i><\/b><\/div>\n
\u00a0\u00a0\u00a0\u00a0 <\/span>C\u2019est une maladie dont l\u2019incubation est relativement longue en moyenne de 6 semaines (15jrs \u00e0 1 an)<\/span><\/div>\n
\u00a0\u00a0\u00a0\u00a0 <\/span>La maladie a un d\u00e9but rapide, la rapidit\u00e9 est d\u2019autant plus grande que la porte d\u2019entr\u00e9 se situe dans une r\u00e9gion riche en terminaisons nerveuses (face, mains, organes g\u00e9nitaux\u2026)<\/span><\/div>\n
b)\u00a0 <\/span><\/span><\/span><\/i><\/b>Phase aigu\u00eb\u00a0:<\/span><\/i><\/b><\/div>\n
\u00a0\u00a0\u00a0\u00a0 <\/span>Peut se manifester de deux types de tableaux diff\u00e9rents\u00a0:<\/span><\/div>\n
\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span>i.\u00a0\u00a0\u00a0 <\/span><\/span><\/span>Rage furieuse\u00a0:<\/span><\/div>\n
\u00a0\u00a0\u00a0\u00a0 <\/span>Pr\u00e9sent\u00a0:<\/span><\/div>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span>un tableau d\u2019excitation psychomotrice majeure (crie, hurlement, cherche \u00e0 mordre, ne tient pas en lace, \u00e9norm\u00e9ment de bave \u00ab\u00a0extr\u00eamement riche en virus\u00a0\u00bb)<\/span><\/div>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span>le sujet a une soif intense avec paralysie de l\u2019oropharynx \u00ab\u00a0spasme hydrophobique\u00a0\u00bb<\/span><\/div>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span>fi\u00e8vre et augmentation de la fr\u00e9quence cardiaque<\/span><\/div>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span>respiration irr\u00e9guli\u00e8re<\/span><\/div>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span>Mort par arr\u00eat respiratoire et cardiaque.<\/span><\/div>\n
\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span>ii.\u00a0\u00a0\u00a0 <\/span><\/span><\/span>Rage paralytique\u00a0:<\/span><\/div>\n
\u00a0\u00a0\u00a0\u00a0 <\/span>Dans ce cas le tableau est moins spectaculaire\u00a0:<\/span><\/div>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span>Douleurs au niveau des membres sup\u00e9rieurs<\/span><\/div>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span>Paralysie flasque au niveau des membres inf\u00e9rieurs et qui se g\u00e9n\u00e9ralise progressivement.<\/span><\/div>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span>Atteinte bulbaire<\/span><\/div>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span>Le sujet est plus ou moins calme<\/span><\/div>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span>Mort cons\u00e9cutive \u00e0 un arr\u00eat cardiaque et respiratoire.<\/u><\/span><\/div>\n
IV.\u00a0\u00a0 <\/span><\/span><\/span><\/b>Diagnostic biologique\u00a0:<\/span><\/b><\/div>\n
v <\/span><\/span>La r\u00e9ponse du laboratoire doit \u00eatre la plus rapidement possible<\/span><\/div>\n
v <\/span><\/span>Le diagnostic se fait essentiellement sur l\u2019animal mordeur ou l\u00e9cheur, il est tr\u00e8s rarement fait chez l\u2019homme<\/span><\/div>\n
v <\/span><\/span>En cas de morsure par un animal, ce dernier doit \u00eatre capturer et dresser chez un v\u00e9t\u00e9rinaire pour l\u2019observation pendant deux semaines\u00a0:<\/span><\/div>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span>Si pendant cette observation, l\u2019animal reste vivant, l\u2019animal est dans ce cas sain<\/span><\/div>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span>Si pendant cette p\u00e9riode l\u2019animal meurt avec des signes de rage \u00e9videntes, dans ce cas l\u2019animal sera d\u00e9capit\u00e9 et la t\u00eate sera envoy\u00e9e au laboratoire (\u00e04\u00b0c) pour faire les pr\u00e9l\u00e8vements sur l\u2019enc\u00e9phale (cervelet), bulbe rachidien, glandes salivaires\u2026<\/span><\/div>\n
v <\/span><\/span>Mise en \u00e9vidence du virus par\u00a0:<\/span><\/div>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span>R\u00e9action d\u2019IFD\u00a0:<\/span><\/div>\n
\u00a0\u00a0\u00a0\u00a0 <\/span>On observe, dans les cellules nerveuses, des inclusions intra-cytoplasmiques caract\u00e9ristiques \u00ab\u00a0corps de Negri\u00a0\u00bb, le r\u00e9sultat est obtenu en quelques heures.<\/span><\/div>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span>Coloration au MGG<\/span><\/div>\n
\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span>Coloration au Sellers<\/span><\/div>\n
\u00a0\u00a0\u00a0\u00a0 <\/span>Ces colorations auront pour objectif de visualiser les corps de Negri.<\/span><\/div>\n
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V.\u00a0\u00a0 <\/span><\/span><\/span><\/b>Traitement et prophylaxie\u00a0:<\/span><\/b><\/div>\n
\u00a0\u00a0\u00a0\u00a0 <\/span>Il n\u2019y a absolument aucun traitement sp\u00e9cifique d\u2019une rage d\u00e9clar\u00e9e humaine ou animale. Toute rage cliniquement observ\u00e9e est mortelle.<\/span><\/div>\n
\u00a0\u00a0\u00a0\u00a0 <\/span>On profite de la longue dur\u00e9e d\u2019incubation de l\u2019infection pour r\u00e9aliser une immunisation active du sujet (vaccin)<\/span><\/div>\n
\u00a0\u00a0\u00a0\u00a0 <\/span>Dans tous les cas o\u00f9 on pense <\/ins>que la contamination est massive, on associe la s\u00e9roth\u00e9rapie (s\u00e9rum antirabique) avec un vaccin antirabique.<\/span><\/div>\n
\u00a0\u00a0\u00a0\u00a0 <\/span>Il existe des vaccins pr\u00e9par\u00e9s sur des cellules fibroblastiques (humaines ou du singe) inactiv\u00e9s par la \u03b2-propiolactone (jamais vaccin vivant)<\/span><\/div>\n<\/div>\n
Le site www.avo6.com propose un contenu \u00e9ditorial pour pr\u00e9server au mieux sa sant\u00e9. Des conseils et astuces qui vous accompagneront dans votre quotidien autour de la nutrition, les m\u00e9dicaments, beaut\u00e9, les analyses m\u00e9dicales, le bien-\u00eatre et les actualit\u00e9s m\u00e9dicales.<\/div>\n","protected":false},"excerpt":{"rendered":"

C\u2019est un virus qui provoque une m\u00e9ningo-enc\u00e9phalite (inflammation des m\u00e9ninges et de tout l\u2019enc\u00e9phale) virale, animale, transmise accidentellement \u00e0 l\u2019homme.…<\/p>\n","protected":false},"author":2,"featured_media":378,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[3],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/avo6.com\/index.php?rest_route=\/wp\/v2\/posts\/30"}],"collection":[{"href":"https:\/\/avo6.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/avo6.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/avo6.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/avo6.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=30"}],"version-history":[{"count":1,"href":"https:\/\/avo6.com\/index.php?rest_route=\/wp\/v2\/posts\/30\/revisions"}],"predecessor-version":[{"id":379,"href":"https:\/\/avo6.com\/index.php?rest_route=\/wp\/v2\/posts\/30\/revisions\/379"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/avo6.com\/index.php?rest_route=\/wp\/v2\/media\/378"}],"wp:attachment":[{"href":"https:\/\/avo6.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=30"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/avo6.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=30"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/avo6.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=30"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}