{"id":861,"date":"2026-10-12T16:58:11","date_gmt":"2026-10-12T16:58:11","guid":{"rendered":"https:\/\/avo6.com\/?page_id=861"},"modified":"2026-10-12T16:58:12","modified_gmt":"2026-10-12T16:58:12","slug":"calculs-de-biochimie","status":"publish","type":"page","link":"https:\/\/avo6.com\/?page_id=861","title":{"rendered":"Calculs de biochimie"},"content":{"rendered":"\n<p>Deux calculs fr\u00e9quents en biochimie clinique, avec leurs conditions de validit\u00e9. Pour convertir des mg\/dL en mmol\/L avant le calcul, utilisez le convertisseur d\u2019unit\u00e9s biologiques.<\/p>\n\n<div class=\"a6t-group a6t-has-tabs\" data-a6t-group=\"biochimie\"><nav class=\"a6t-tabs\" aria-label=\"Outils de cette page\"><ul><li><a href=\"#osmolalite\" data-a6t-tab=\"osmolalite\">Osmolalit\u00e9 calcul\u00e9e<\/a><\/li><li><a href=\"#ldl-friedewald\" data-a6t-tab=\"ldl-friedewald\">LDL-cholest\u00e9rol (Friedewald)<\/a><\/li><\/ul><\/nav>\t<section class=\"a6t-tool\" id=\"osmolalite\" data-a6t-panel aria-labelledby=\"a6t-osmolalite-title\">\n\t\t<h2 id=\"a6t-osmolalite-title\" class=\"a6t-title\">Osmolalit\u00e9 calcul\u00e9e et trou osmolaire<\/h2>\n\t\t<p class=\"a6t-lead\">Osmolalit\u00e9 plasmatique calcul\u00e9e \u00e0 partir du sodium, du glucose et de l\u2019ur\u00e9e, et trou osmolaire si l\u2019osmolalit\u00e9 mesur\u00e9e est connue.<\/p>\n\n\t\t<form class=\"calc a6t-form\" data-a6t-tool=\"osmolalite\" novalidate autocomplete=\"off\" aria-label=\"Calculateur : Osmolalit\u00e9 calcul\u00e9e\">\n\t\t\t\t\t\t<fieldset class=\"a6t-fieldset\" disabled>\n\t\t\t\t<legend class=\"screen-reader-text\">Donn\u00e9es \u00e0 saisir<\/legend>\n\t\t\t\t<div class=\"field a6t-field\"><label for=\"a6t-osmolalite-na\">Sodium (mmol\/L)<\/label><input id=\"a6t-osmolalite-na\" name=\"na\" type=\"text\" inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" value=\"\" aria-describedby=\"a6t-osmolalite-na-err\" aria-required=\"true\"><span class=\"error\" id=\"a6t-osmolalite-na-err\" data-a6t-err-for=\"na\" aria-live=\"polite\"><\/span><\/div><div class=\"field a6t-field\"><label for=\"a6t-osmolalite-glucose\">Glucose (mmol\/L)<\/label><input id=\"a6t-osmolalite-glucose\" name=\"glucose\" type=\"text\" inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" value=\"\" aria-describedby=\"a6t-osmolalite-glucose-err\" aria-required=\"true\"><span class=\"error\" id=\"a6t-osmolalite-glucose-err\" data-a6t-err-for=\"glucose\" aria-live=\"polite\"><\/span><\/div><div class=\"field a6t-field\"><label for=\"a6t-osmolalite-uree\">Ur\u00e9e (mmol\/L)<\/label><input id=\"a6t-osmolalite-uree\" name=\"uree\" type=\"text\" inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" value=\"\" aria-describedby=\"a6t-osmolalite-uree-err\" aria-required=\"true\"><span class=\"error\" id=\"a6t-osmolalite-uree-err\" data-a6t-err-for=\"uree\" aria-live=\"polite\"><\/span><\/div><div class=\"field a6t-field\"><label for=\"a6t-osmolalite-measured\">Osmolalit\u00e9 mesur\u00e9e (mOsm\/kg) \u2014 facultatif<\/label><input id=\"a6t-osmolalite-measured\" name=\"measured\" type=\"text\" inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" value=\"\" aria-describedby=\"a6t-osmolalite-measured-err\"><span class=\"error\" id=\"a6t-osmolalite-measured-err\" data-a6t-err-for=\"measured\" aria-live=\"polite\"><\/span><\/div>\t\t\t\t<div class=\"a6t-actions\">\n\t\t\t\t\t<button type=\"submit\" class=\"btn btn-primary\">Calculer<\/button>\n\t\t\t\t\t<button type=\"reset\" class=\"btn btn-ghost\">R\u00e9initialiser<\/button>\n\t\t\t\t\t<button type=\"button\" class=\"a6t-linkbtn\" data-a6t-example>Essayer l\u2019exemple<\/button>\n\t\t\t\t<\/div>\n\t\t\t<\/fieldset>\n\t\t\t<p class=\"error a6t-formerror\" data-a6t-err-for=\"_\" role=\"alert\"><\/p>\n\n\t\t\t<div class=\"calc-result a6t-result\" role=\"status\" aria-live=\"polite\" tabindex=\"-1\" hidden>\n\t\t\t\t<div class=\"a6t-main\"><\/div>\n\t\t\t\t<ul class=\"a6t-lines\"><\/ul>\n\t\t\t\t<div class=\"a6t-chart\"><\/div>\n\t\t\t\t<div class=\"a6t-table\"><\/div>\n\t\t\t\t<p class=\"a6t-formula\"><\/p>\n\t\t\t\t<ul class=\"a6t-notes\"><\/ul>\n\t\t\t\t<p class=\"hint\">R\u00e9sultat indicatif, \u00e0 interpr\u00e9ter par un professionnel de sant\u00e9.<\/p>\n\t\t\t\t<div class=\"a6t-result-actions\">\n\t\t\t\t\t<button type=\"button\" class=\"btn btn-ghost\" data-a6t-copy>Copier le r\u00e9sultat<\/button>\n\t\t\t\t\t<span class=\"a6t-copied\" aria-live=\"polite\"><\/span>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\t\t\t<noscript><p class=\"notice\">Ce calculateur fonctionne dans votre navigateur et n\u00e9cessite JavaScript. La formule et un exemple sont d\u00e9taill\u00e9s ci-dessous.<\/p><\/noscript>\n\t\t\t<script type=\"application\/json\" class=\"a6t-example-data\">{\"na\":\"140\",\"glucose\":\"5\",\"uree\":\"5\",\"measured\":\"300\"}<\/script>\n\t\t<\/form>\n\n\t\t<div class=\"a6t-doc\">\n\t\t\t<h3>Formule<\/h3>\n\t\t\t<div class=\"a6t-formula-box\"><p>Osmolalit\u00e9 calcul\u00e9e = 2 \u00d7 Na + glucose + ur\u00e9e (toutes en mmol\/L)<\/p><p>Trou osmolaire = osmolalit\u00e9 mesur\u00e9e \u2212 osmolalit\u00e9 calcul\u00e9e.<\/p><\/div>\n\n\t\t\t<h3>Unit\u00e9s<\/h3>\n\t\t\t<p>mmol\/L pour toutes les entr\u00e9es (utilisez le convertisseur pour les mg\/dL) ; r\u00e9sultat en mOsm\/kg.<\/p>\n\n\t\t\t<h3>Exemple<\/h3>\n\t\t\t<p>Na 140, glucose 5 et ur\u00e9e 5 mmol\/L : 2 \u00d7 140 + 5 + 5 = 290 mOsm\/kg ; mesur\u00e9e 300 \u2192 trou osmolaire de 10.<\/p>\n\n\t\t\t<h3>Limites<\/h3>\n\t\t\t<ul>\n\t\t\t\t\t\t\t\t\t<li>Plusieurs formules existent ; celle-ci est la plus courante en unit\u00e9s SI. Les seuils de trou osmolaire d\u00e9pendent de la formule et du laboratoire.<\/li>\n\t\t\t\t\t\t\t\t\t<li>Mesur\u00e9e et calcul\u00e9e doivent provenir du m\u00eame \u00e9chantillon. Un trou osmolaire normal n\u2019exclut pas une intoxication (m\u00e9tabolisation d\u00e9j\u00e0 avanc\u00e9e).<\/li>\n\t\t\t\t\t\t\t<\/ul>\n\n\t\t\t<h3>R\u00e9f\u00e9rences<\/h3>\n\t\t\t<ol class=\"a6t-refs\">\n\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/ficm.ac.uk\/node\/3496\" rel=\"noopener\" target=\"_blank\">Faculty of Intensive Care Medicine. What is osmolal gap and what causes increased osmolal gap? (2022).<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.healthcare.uiowa.edu\/path_handbook\/Appendix\/Chem\/OSMO_GAP.html\" rel=\"noopener\" target=\"_blank\">University of Iowa Health Care. Osmolality Gap \u2014 Calculation and Interpretation. Laboratory Services Handbook.<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<\/ol>\n\t\t\t<p class=\"a6t-verified\">Formule v\u00e9rifi\u00e9e par rapport aux r\u00e9f\u00e9rences ci-dessus le 12 octobre 2026.<\/p>\n\t\t<\/div>\n\t<\/section>\n\t\t<section class=\"a6t-tool\" id=\"ldl-friedewald\" data-a6t-panel aria-labelledby=\"a6t-ldl-friedewald-title\">\n\t\t<h2 id=\"a6t-ldl-friedewald-title\" class=\"a6t-title\">LDL-cholest\u00e9rol calcul\u00e9 (Friedewald)<\/h2>\n\t\t<p class=\"a6t-lead\">LDL-cholest\u00e9rol estim\u00e9 \u00e0 partir du cholest\u00e9rol total, du HDL et des triglyc\u00e9rides, et cholest\u00e9rol non-HDL.<\/p>\n\n\t\t<form class=\"calc a6t-form\" data-a6t-tool=\"ldl-friedewald\" novalidate autocomplete=\"off\" aria-label=\"Calculateur : LDL-cholest\u00e9rol (Friedewald)\">\n\t\t\t\t\t\t<fieldset class=\"a6t-fieldset\" disabled>\n\t\t\t\t<legend class=\"screen-reader-text\">Donn\u00e9es \u00e0 saisir<\/legend>\n\t\t\t\t<fieldset class=\"field a6t-field\"><legend>Unit\u00e9<\/legend><div class=\"seg\"><label><input type=\"radio\" name=\"unit\" value=\"mmol\/L\" checked='checked' aria-describedby=\"a6t-ldl-friedewald-unit-err\"> <span>mmol\/L<\/span><\/label><label><input type=\"radio\" name=\"unit\" value=\"mg\/dL\" aria-describedby=\"a6t-ldl-friedewald-unit-err\"> <span>mg\/dL<\/span><\/label><\/div><span class=\"error\" id=\"a6t-ldl-friedewald-unit-err\" data-a6t-err-for=\"unit\" aria-live=\"polite\"><\/span><\/fieldset><div class=\"field a6t-field\"><label for=\"a6t-ldl-friedewald-ct\">Cholest\u00e9rol total<\/label><input id=\"a6t-ldl-friedewald-ct\" name=\"ct\" type=\"text\" inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" value=\"\" aria-describedby=\"a6t-ldl-friedewald-ct-err\" aria-required=\"true\"><span class=\"error\" id=\"a6t-ldl-friedewald-ct-err\" data-a6t-err-for=\"ct\" aria-live=\"polite\"><\/span><\/div><div class=\"field a6t-field\"><label for=\"a6t-ldl-friedewald-hdl\">HDL-cholest\u00e9rol<\/label><input id=\"a6t-ldl-friedewald-hdl\" name=\"hdl\" type=\"text\" inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" value=\"\" aria-describedby=\"a6t-ldl-friedewald-hdl-err\" aria-required=\"true\"><span class=\"error\" id=\"a6t-ldl-friedewald-hdl-err\" data-a6t-err-for=\"hdl\" aria-live=\"polite\"><\/span><\/div><div class=\"field a6t-field\"><label for=\"a6t-ldl-friedewald-tg\">Triglyc\u00e9rides<\/label><input id=\"a6t-ldl-friedewald-tg\" name=\"tg\" type=\"text\" inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" value=\"\" aria-describedby=\"a6t-ldl-friedewald-tg-err\" aria-required=\"true\"><span class=\"error\" id=\"a6t-ldl-friedewald-tg-err\" data-a6t-err-for=\"tg\" aria-live=\"polite\"><\/span><\/div>\t\t\t\t<div class=\"a6t-actions\">\n\t\t\t\t\t<button type=\"submit\" class=\"btn btn-primary\">Calculer<\/button>\n\t\t\t\t\t<button type=\"reset\" class=\"btn btn-ghost\">R\u00e9initialiser<\/button>\n\t\t\t\t\t<button type=\"button\" class=\"a6t-linkbtn\" data-a6t-example>Essayer l\u2019exemple<\/button>\n\t\t\t\t<\/div>\n\t\t\t<\/fieldset>\n\t\t\t<p class=\"error a6t-formerror\" data-a6t-err-for=\"_\" role=\"alert\"><\/p>\n\n\t\t\t<div class=\"calc-result a6t-result\" role=\"status\" aria-live=\"polite\" tabindex=\"-1\" hidden>\n\t\t\t\t<div class=\"a6t-main\"><\/div>\n\t\t\t\t<ul class=\"a6t-lines\"><\/ul>\n\t\t\t\t<div class=\"a6t-chart\"><\/div>\n\t\t\t\t<div class=\"a6t-table\"><\/div>\n\t\t\t\t<p class=\"a6t-formula\"><\/p>\n\t\t\t\t<ul class=\"a6t-notes\"><\/ul>\n\t\t\t\t<p class=\"hint\">R\u00e9sultat indicatif, \u00e0 interpr\u00e9ter par un professionnel de sant\u00e9.<\/p>\n\t\t\t\t<div class=\"a6t-result-actions\">\n\t\t\t\t\t<button type=\"button\" class=\"btn btn-ghost\" data-a6t-copy>Copier le r\u00e9sultat<\/button>\n\t\t\t\t\t<span class=\"a6t-copied\" aria-live=\"polite\"><\/span>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\t\t\t<noscript><p class=\"notice\">Ce calculateur fonctionne dans votre navigateur et n\u00e9cessite JavaScript. La formule et un exemple sont d\u00e9taill\u00e9s ci-dessous.<\/p><\/noscript>\n\t\t\t<script type=\"application\/json\" class=\"a6t-example-data\">{\"unit\":\"mmol\\\/L\",\"ct\":\"5,2\",\"hdl\":\"1,3\",\"tg\":\"1,5\"}<\/script>\n\t\t<\/form>\n\n\t\t<div class=\"a6t-doc\">\n\t\t\t<h3>Formule<\/h3>\n\t\t\t<div class=\"a6t-formula-box\"><p>mmol\/L : LDL = CT \u2212 HDL \u2212 TG \/ 2,2<\/p><p>mg\/dL : LDL = CT \u2212 HDL \u2212 TG \/ 5<\/p><p>Non-HDL = CT \u2212 HDL.<\/p><\/div>\n\n\t\t\t<h3>Unit\u00e9s<\/h3>\n\t\t\t<p>Toutes les valeurs dans la m\u00eame unit\u00e9 (mmol\/L ou mg\/dL).<\/p>\n\n\t\t\t<h3>Exemple<\/h3>\n\t\t\t<p>CT 5,2, HDL 1,3, TG 1,5 mmol\/L : 5,2 \u2212 1,3 \u2212 1,5 \/ 2,2 = 3,22 mmol\/L.<\/p>\n\n\t\t\t<h3>Limites<\/h3>\n\t\t\t<ul>\n\t\t\t\t\t\t\t\t\t<li>Non applicable si les triglyc\u00e9rides sont \u2265 4,5 mmol\/L (\u2265 400 mg\/dL) : un dosage direct est n\u00e9cessaire.<\/li>\n\t\t\t\t\t\t\t\t\t<li>Moins exacte lorsque le LDL est bas ou les triglyc\u00e9rides \u00e9lev\u00e9s ; pr\u00e9l\u00e8vement \u00e0 jeun recommand\u00e9 pour cette formule.<\/li>\n\t\t\t\t\t\t\t\t\t<li>Les objectifs de LDL d\u00e9pendent du risque cardiovasculaire individuel.<\/li>\n\t\t\t\t\t\t\t<\/ul>\n\n\t\t\t<h3>R\u00e9f\u00e9rences<\/h3>\n\t\t\t<ol class=\"a6t-refs\">\n\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/4337382\/\" rel=\"noopener\" target=\"_blank\">Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499-502.<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.msdmanuals.com\/iframe\/manual\/medical-calculators\/friedewald_si.htm\" rel=\"noopener\" target=\"_blank\">Manuels MSD. Friedewald Equation for LDL-C (SI units) \u2014 limite de validit\u00e9 TG &lt; 4,5 mmol\/L.<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<\/ol>\n\t\t\t<p class=\"a6t-verified\">Formule v\u00e9rifi\u00e9e par rapport aux r\u00e9f\u00e9rences ci-dessus le 12 octobre 2026.<\/p>\n\t\t<\/div>\n\t<\/section>\n\t<aside class=\"box box-warning a6t-disclaimer\" role=\"note\"><strong>Avertissement :<\/strong> ces outils sont p\u00e9dagogiques. Les calculs sont effectu\u00e9s dans votre navigateur ; aucune valeur n\u2019est enregistr\u00e9e ni transmise. Ils ne posent pas de diagnostic et ne remplacent pas l\u2019avis d\u2019un m\u00e9decin, d\u2019un biologiste ou d\u2019un pharmacien.<\/aside><nav class=\"a6t-related\" aria-labelledby=\"a6t-rel-biochimie\"><h2 id=\"a6t-rel-biochimie\">Outils associ\u00e9s<\/h2><ul><li><a href=\"https:\/\/avo6.com\/?page_id=849\">Convertisseur d\u2019unit\u00e9s biologiques<\/a><\/li><li><a href=\"https:\/\/avo6.com\/?page_id=871\">Gaz du sang et \u00e9quilibre acide-base<\/a><\/li><li><a href=\"https:\/\/avo6.com\/?page_id=855\">Calc\u00e9mie corrig\u00e9e par l\u2019albumine<\/a><\/li><li><a href=\"https:\/\/avo6.com\/?page_id=857\">Tous les outils de biologie m\u00e9dicale<\/a><\/li><\/ul><\/nav><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Deux calculs fr\u00e9quents en biochimie clinique, avec leurs conditions de validit\u00e9. Pour convertir des mg\/dL en mmol\/L avant le calcul, utilisez le convertisseur d\u2019unit\u00e9s\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"class_list":["post-861","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.3 - aioseo.com -->\n\t<meta name=\"description\" content=\"Deux calculs fr\u00e9quents en biochimie clinique, avec leurs conditions de validit\u00e9. 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